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The monthly protocol may involve a cycle of regular dosing for 2-3 months straight, followed by a one-month break

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A study has meticulously analyzed the metabolic, proteomic, and functional characteristics of THY1 + fibroblast-like synoviocytes in OA patients, uncovering an elevated expression of pyruvate dehydrogenase kinase 3 as a distinctive feature of proliferative THY1 + FLS in these individuals and reveals how metabolic changes in synovial fibroblasts contribute to OA [67]

Reconstitute the sample by adding 100 l of acetonitrile: water (1:1), vortex for 30 s, and sonicate for 5 min on ice

Once dosage is clear, timing becomes the next lever

[75] Sun YH, Nfor ON, Huang JY, Liaw YP